Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | CFTR | P13569 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.47 |
| ▸ | PHGDH | O43175 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MPL | P40238 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373268 | 0.88 | TRPA1 (0.55) | LMNASIRT5ALKTRPA1TRPV3 | |
| SCHEMBL9370487 | 0.87 | GSTO1 (0.53) | LMNASIRT5ALKTRPA1TRPV4 | |
| SCHEMBL9370793 | 0.86 | SIRT5 (0.49) | LMNASIRT5TRPA1CFTRAR | |
| SCHEMBL9375923 | 0.84 | MAPT (0.53) | LMNAALKPHGDHMAPTMAPK1 | |
| SCHEMBL9371712 | 0.83 | SIRT5 (0.46) | LMNASIRT5TRPA1CFTRAR | |
| SCHEMBL9376513 | 0.82 | MEN1 (0.64) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL9376491 | 0.80 | MAOA (0.57) | CSNK2A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL9370647 | 0.79 | KMT2A (0.54) | LMNAMAPTMAPK1MEN1KMT2A | |
| SCHEMBL9370316 | 0.79 | MAPT (0.57) | LMNASIRT5ALKPHGDHMAPT | |
| SCHEMBL9370746 | 0.79 | MAPT (0.53) | LMNAMAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |