Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.68 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343775 | 0.83 | CYP11B2 (0.40) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL7349060 | 0.82 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7342699 | 0.76 | USP30 (0.46) | PDE3BPDE3AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7341201 | 0.75 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7344414 | 0.69 | MAP3K5 (0.38) | — | |
| SCHEMBL9589604 | 0.69 | F10 (0.38) | ALDH1A1 | |
| SCHEMBL9730876 | 0.68 | CYP11B2 (0.41) | PDE3BPDE3AALDH1A1 | |
| Iodide SCHEMBL9731026 | 0.67 | CYP11B2 (0.41) | PDE3BPDE3A | |
| SCHEMBL7343441 | 0.67 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7419902 | 0.67 | ALDH1A1 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011256-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZINYLTETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |