Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707114 | 0.86 | ALDH1A1 (0.50) | ACENPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL11547220 | 0.83 | NPC1 (0.59) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9707098 | 0.83 | ACE (0.43) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9707052 | 0.82 | ACE (0.46) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9707178 | 0.77 | RAB9A (0.63) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11545636 | 0.76 | KDM4E (0.53) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11544959 | 0.75 | DPP4 (0.49) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6788316 | 0.74 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6788307 | 0.74 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10351951 | 0.74 | L3MBTL1 (0.43) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |