Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707090 | 0.88 | LMNA (0.44) | ACELMNAL3MBTL1 | |
| SCHEMBL9707078 | 0.83 | ACE (0.49) | ACECYP2C19CHRM2CHRM4CHRM1 | |
| SCHEMBL9707052 | 0.79 | ACE (0.46) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9707036 | 0.78 | ALDH1A1 (0.57) | LMNACYP2C19 | |
| SCHEMBL11547220 | 0.75 | NPC1 (0.59) | ACECYP2C19CHRM2CHRM4CHRM1 | |
| SCHEMBL11544959 | 0.75 | DPP4 (0.49) | ACELMNACYP2C19CHRM2CHRM4 | |
| SCHEMBL9510252 | 0.75 | ALDH1A1 (0.46) | LMNACYP2C19 | |
| Hydrochloric Acid SCHEMBL9510629 | 0.74 | ALDH1A1 (0.45) | LMNACYP2C19 | |
| SCHEMBL8309788 | 0.73 | VCAM1 (0.55) | LMNA | |
| SCHEMBL9814007 | 0.73 | SMN1; SMN2 (0.60) | LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | claimed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | claimed |
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |