Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515779 | 0.87 | NR4A1 (0.52) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL286256 | 0.81 | CES2 (0.57) | MAPTHSD17B1HSD17B2KDM4EHPGD | |
| SCHEMBL8569750 | 0.79 | CDC25B (0.59) | KMT2ACNR2CNR1KDM4EHPGD | |
| SCHEMBL9856912 | 0.79 | GCGR (0.67) | NPC1RAB9AKMT2ACNR2CNR1 | |
| SCHEMBL6750240 | 0.75 | RAB9A (0.54) | NPC1RAB9AKMT2ACNR2CNR1 | |
| SCHEMBL4455035 | 0.73 | ALDH1A1 (0.59) | MAPTHPGDALDH1A1 | |
| SCHEMBL16549911 | 0.73 | RAB9A (0.51) | NPC1RAB9AKMT2ACNR2CNR1 | |
| SCHEMBL21243055 | 0.73 | CDC25B (0.54) | KMT2ACNR2CNR1MAPTKDM4E | |
| SCHEMBL383491 | 0.73 | RAB9A (0.51) | NPC1RAB9AKMT2ACNR2CNR1 | |
| SCHEMBL28813458 | 0.73 | CACNA1B (0.59) | NPC1RAB9AKMT2ACNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | disclosed |