Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | BCHE | P06276 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10457641 | 0.92 | ALOX5 (0.56) | ALOX5BCHEPTGS1PTGS2LMNA | |
| SCHEMBL8519393 | 0.82 | BCHE (0.63) | ALOX5BCHEPTGS1PTGS2LMNA | |
| SCHEMBL26633561 | 0.82 | BCHE (0.67) | BCHELMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13652546 | 0.80 | LMNA (0.61) | BCHELMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2755055 | 0.80 | ALOX5 (1.00) | ALOX5PTGS1PTGS2MAOB | |
| SCHEMBL7400144 | 0.80 | BCHE (0.63) | ALOX5BCHE | |
| SCHEMBL9781762 | 0.79 | ALDH1A1 (0.57) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25180069 | 0.79 | ALOX5 (0.57) | ALOX5BCHELMNAMEN1KMT2A | |
| SCHEMBL8935238 | 0.78 | LTA4H (0.67) | BCHEKMT2AADAMTS5MAOB | |
| SCHEMBL8389369 | 0.78 | NPC1 (0.71) | ALOX5BCHELMNAKMT2AADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |