Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707258 | 0.86 | PTGS2 (0.49) | PTGS2ALOX5PTGS1 | |
| SCHEMBL9707420 | 0.81 | ALOX5 (0.70) | PTGS2ALOX5PTGS1LTA4H | |
| SCHEMBL9707287 | 0.76 | ALOX5 (0.52) | PTGS2ALOX5PTGS1 | |
| SCHEMBL9878036 | 0.75 | PTGES (0.45) | PTGS2ALOX5 | |
| SCHEMBL5598667 | 0.75 | RAB9A (0.58) | PTGS2GAASMN1; SMN2LTA4HALDH1A1 | |
| SCHEMBL3543339 | 0.75 | LTA4H (0.58) | PTGS2ADAMTS4P2RX3LTA4HALDH1A1 | |
| SCHEMBL5024073 | 0.75 | PTGS2 (0.50) | PTGS2ADAMTS4SMN1; SMN2LTA4HKDM4E | |
| SCHEMBL9707249 | 0.74 | ALOX5 (1.00) | PTGS2ALOX5PTGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3242252 | 0.74 | LTA4H (0.42) | PTGS2ADAMTS4LTA4HKDM4EALDH1A1 | |
| SCHEMBL11143982 | 0.73 | PTGS2 (0.57) | PTGS2SMN1; SMN2LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |