Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711803 | 0.93 | HTR1A (0.40) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9711754 | 0.83 | POLB (0.43) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9711736 | 0.81 | LMNA (0.35) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9711779 | 0.79 | PKM (0.42) | MAPTALDH1A1 | |
| SCHEMBL9584569 | 0.79 | ALDH1A1 (0.44) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9711750 | 0.75 | POLB (0.43) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9711767 | 0.74 | ALDH1A1 (0.46) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9585096 | 0.73 | ALDH1A1 (0.51) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL9712046 | 0.72 | NOTUM (0.49) | LMNAALDH1A1 | |
| SCHEMBL10508789 | 0.71 | ALDH1A1 (0.36) | LMNAALDH1A1MTNR1AMTNR1BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303227-B1 | ETHERS AND THIOETHERS HAVING THERAPEUTICAL ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-02-05 | — | — | EP | disclosed |