Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713853 | 0.87 | PKM (0.67) | PKMCYP2C19LMNANPC1ALDH1A1 | |
| SCHEMBL9713938 | 0.85 | HTR6 (0.50) | PKMCYP2C19HTR6TSHRLMNA | |
| SCHEMBL8190992 | 0.83 | TDP1 (0.43) | PKMCYP2C19TSHRCYP3A4CYP2C9 | |
| SCHEMBL9714078 | 0.83 | CA4 (0.46) | PKMCYP2C19HTR6TSHRLMNA | |
| SCHEMBL9714080 | 0.83 | GAA (0.51) | PKMCYP2C19HTR6TSHRLMNA | |
| Hydrochloric Acid SCHEMBL9713979 | 0.82 | HTR6 (0.47) | PKMCYP2C19HTR6TSHRLMNA | |
| SCHEMBL11758764 | 0.81 | L3MBTL1 (0.41) | PKMCYP2C19TSHRCYP3A4CYP2C9 | |
| SCHEMBL10612152 | 0.81 | ALDH1A1 (0.46) | PKMCYP2C19TSHRCYP3A4CYP2C9 | |
| SCHEMBL4638644 | 0.81 | ALDH1A1 (0.44) | PKMCYP2C19TSHRCYP3A4CYP2C9 | |
| SCHEMBL4349616 | 0.79 | L3MBTL1 (0.42) | PKMCYP2C19TSHRCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |