Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | C1S | P09871 | 4/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714294 | 0.84 | CA5A (0.48) | CA5AKDM4EALDH1A1ADORA2AADORA1 | |
| SCHEMBL10568675 | 0.82 | ALDH1A1 (0.49) | KDM4EALDH1A1TSHRMAPK1MEN1 | |
| SCHEMBL9714307 | 0.82 | CA5A (0.46) | CA5AKDM4EALDH1A1ADORA2AADORA1 | |
| SCHEMBL31333084 | 0.79 | CA5A (0.52) | CA5AADORA2AADORA1TSHRMAPK1 | |
| SCHEMBL31333042 | 0.77 | CA5A (0.44) | CA5ATSHRPKMMAPK1CD38 | |
| SCHEMBL18050891 | 0.76 | TSHR (0.47) | CA5AKDM4EALDH1A1TSHRPKM | |
| SCHEMBL9714543 | 0.75 | LMNA (0.55) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL9714280 | 0.74 | CA5A (0.57) | CA5AKDM4EALDH1A1PKMCD38 | |
| SCHEMBL10571269 | 0.73 | ALDH1A1 (0.48) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9714161 | 0.72 | CA5A (0.48) | CA5AKDM4EALDH1A1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |