Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714601 | 0.85 | ESR2 (0.36) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL9714779 | 0.84 | CYP3A4 (0.33) | KDM4EALDH1A1LMNACYP3A4TDP1 | |
| SCHEMBL9714785 | 0.79 | CTSB (0.35) | CYP3A4TDP1TSHRCTSBCTSL | |
| SCHEMBL9714816 | 0.76 | SLC6A2 (0.34) | CYP3A4TDP1TSHRCTSBCTSL | |
| SCHEMBL7711209 | 0.74 | CYP1A2 (0.34) | KDM4EALDH1A1LMNACYP3A4TSHR | |
| SCHEMBL9714646 | 0.74 | MEN1 (0.35) | KDM4ECYP3A4TDP1TSHR | |
| SCHEMBL9714823 | 0.73 | MAOA (0.35) | — | |
| SCHEMBL9714810 | 0.73 | ENPP2 (0.42) | KDM4ELMNACYP3A4TDP1TSHR | |
| SCHEMBL9714736 | 0.73 | MAOA (0.42) | ALDH1A1LMNACYP3A4TDP1TSHR | |
| SCHEMBL181368 | 0.73 | TRPA1 (0.46) | ALDH1A1LMNACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |