Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL976233 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL6073416 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL17965917 | 0.97 | TSHR (0.45) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL11755069 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL11755064 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL29134533 | 0.91 | LMNA (0.43) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3929198 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3839105 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL3930218 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL3930219 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110225965-A | Detergent or cleaning agent part with at least two phases | 汉高股份有限及两合公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-107980051-A | Composition containing rosin ester and ethylene polymer | 亚利桑那化学品有限责任公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-101374923-A | Scale inhibiting well treatment | CHAMPION TECHNOLOGIES LTD (GB) | 2009-02-25 | — | — | CN | disclosed |
| EP-0479560-A2 | Stabilized thermoplastic resin composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-04-08 | — | — | EP | disclosed |