Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Anhydride SCHEMBL893612 | 0.93 | LMNA (0.50) | LMNAAKT1ALOX15HSD17B10 | |
| Maleic Anhydride SCHEMBL28221693 | 0.93 | LMNA (0.50) | LMNAAKT1ALOX15HSD17B10 | |
| Maleic Anhydride SCHEMBL4274117 | 0.91 | LMNA (0.48) | LMNAAKT1ALOX15HSD17B10 | |
| Fumaric Acid SCHEMBL6073416 | 0.91 | TSHR (0.47) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL976233 | 0.91 | TSHR (0.47) | LMNATSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL9715339 | 0.91 | TSHR (0.47) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL17965917 | 0.89 | TSHR (0.45) | LMNATSHRTP53EGLN1EGLN3 | |
| Maleic Anhydride SCHEMBL11078903 | 0.87 | LMNA (0.43) | LMNAALDH1A1KMT2AAKT1ALOX15 | |
| Maleic Anhydride SCHEMBL28798969 | 0.85 | LMNA (0.42) | LMNATSHRTP53ALDH1A1AKT1 | |
| Maleic Anhydride SCHEMBL29267683 | 0.85 | LMNA (0.42) | LMNATSHRTP53ALDH1A1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117043203-A | Ethylene- (meth) acrylate elastomer and method for producing same | 优迈特株式会社 | 2023-11-10 | — | — | CN | disclosed |
| CN-116997580-A | Ethylene- (meth) acrylate elastomer and method for producing same | 优迈特株式会社 | 2023-11-03 | — | — | CN | disclosed |