Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6073416 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL9715339 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL17965917 | 0.97 | TSHR (0.45) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL11755069 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL11755064 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL29134533 | 0.91 | LMNA (0.43) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3929198 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3839105 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL3930218 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL3930219 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210130057-A1 | Water-Soluble Packets | MONOSOL, LLC | 2021-05-06 | — | — | US | claimed |
| CN-109942761-A | A kind of preparation method containing sulfonic epoxy succinic acid polymer | 河北省科学院能源研究所 | 2019-06-28 | — | — | CN | claimed |
| US-10201909-B2 | Treated wood material | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-02-12 | — | — | US | claimed |
| US-20170129131-A1 | TREATED POROUS MATERIAL | DOW GLOBAL TECHNOLOGIES LLC | 2017-05-11 | — | — | US | claimed |
| EP-3160698-A1 | TREATED POROUS MATERIAL | Dow Global Technologies LLC (US) | 2017-05-03 | — | — | EP | claimed |
| CN-105399904-A | Mould-proof and anticorrosion type polycarboxylate superplasticizer and preparation method thereof | SHAANXI KZJ NEW MAT CO LTD | 2016-03-16 | — | — | CN | claimed |
| WO-2016003996-A1 | TREATED POROUS MATERIAL | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-01-07 | — | — | WO | claimed |
| US-8859429-B2 | Polishing agent for copper polishing and polishing method using same | HITACHI CHEMICAL CO., LTD. (JP) | 2014-10-14 | — | — | US | claimed |
| US-20120245278-A1 | CURABLE FIBERGLASS BINDER COMPRISING A POLYACETAL OR POLYKETAL | SHOOSHTARI KIARASH ALAVI (US) | 2012-09-27 | — | — | US | claimed |
| US-20120160804-A1 | POLISHING AGENT FOR COPPER POLISHING AND POLISHING METHOD USING SAME | HITACHI CHEMICAL CO., LTD. (JP) | 2012-06-28 | — | — | US | claimed |
| US-20070083004-A1 | Curable fiberglass binder comprising a polyacetal or polyketal | JOHNS MANVILLE | 2007-04-12 | — | — | US | claimed |
| US-7005004-B2 | mixtures of carbon black, azo dyes such as tetrasodium-6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphanatophenyl)azo]-1-naphth-1-yl]azo]naphthalene-2,7-disulphonate, water and wetting agents, used in inks or paints having high optical density | DEGUSSA AG (DE) | 2006-02-28 | — | — | US | claimed |
| US-20050178291-A1 | mixtures of carbon black, azo dyes such as tetrasodium-6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphanatophenyl)azo]-1-naphth-1-yl]azo]naphthalene-2,7-disulphonate, water and wetting agents, used in inks or paints having high optical density | UBS LIMITED (GB) | 2005-08-18 | — | — | US | claimed |
| US-6794482-B2 | Adhesion promoter additive comprising an unsaturated, amorphous polyester | DEGUSSA AG (DE) | 2004-09-21 | — | — | US | claimed |
| US-20040054075-A1 | Adhesion promoter additive comprising an unsaturated, amorphous polyester | DEGUSSA AG (DE) | 2004-03-18 | — | — | US | claimed |
| CN-1286139-A | Improved catalyst for preparing 1,4-butanediol by hydrogenation of maleic acid | MOBIL OIL (US) | 2001-03-07 | — | — | CN | claimed |
| US-5866628-A | FORMALDEHYDE OLIGOMER OR A CYCLIC-ALIPHATIC OLIGOMER; FLUORESCENT DYE; AND PHOTOPOLYMERIZABLE VEHICLE. | DAY-GLO COLOR CORP. (US) | 1999-02-02 | — | — | US | claimed |
| US-5240697-A | Potassium pyrophosphate; potassium nitrate, oxalate or citrate ; polymeric stabilizer | COLGATE-PALMOLIVE COMPANY (US) | 1993-08-31 | — | — | US | claimed |
| US-5221136-A | Chemical resistance thermoforming plastic liner | BASF CORPORATION (US) | 1993-06-22 | — | — | US | claimed |
| US-4116903-A | Alkyd-supported emulsion interpolymers and methods for preparation | P.R.A. LABORATORIES INCORPORATED (US) | 1978-09-26 | — | — | US | claimed |