Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL976233 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL9715339 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL17965917 | 0.97 | TSHR (0.45) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL11755069 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL11755064 | 0.91 | TSHR (0.39) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL29134533 | 0.91 | LMNA (0.43) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3929198 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Anhydride SCHEMBL3839105 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Maleic Acid SCHEMBL3930218 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT | |
| Fumaric Acid SCHEMBL3930219 | 0.89 | TSHR (0.38) | TSHRTP53EGLN1EGLN3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016072941-A1 | DIETHANOLAMINE DERIVATIVES AND A PREPARATION METHOD THEREOF | PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) | 2016-05-12 | — | — | WO | claimed |
| US-7005004-B2 | mixtures of carbon black, azo dyes such as tetrasodium-6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphanatophenyl)azo]-1-naphth-1-yl]azo]naphthalene-2,7-disulphonate, water and wetting agents, used in inks or paints having high optical density | DEGUSSA AG (DE) | 2006-02-28 | — | — | US | claimed |
| US-20050178291-A1 | mixtures of carbon black, azo dyes such as tetrasodium-6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphanatophenyl)azo]-1-naphth-1-yl]azo]naphthalene-2,7-disulphonate, water and wetting agents, used in inks or paints having high optical density | UBS LIMITED (GB) | 2005-08-18 | — | — | US | claimed |
| US-5240697-A | Potassium pyrophosphate; potassium nitrate, oxalate or citrate ; polymeric stabilizer | COLGATE-PALMOLIVE COMPANY (US) | 1993-08-31 | — | — | US | claimed |
| US-5221136-A | Chemical resistance thermoforming plastic liner | BASF CORPORATION (US) | 1993-06-22 | — | — | US | claimed |
| WO-2023162603-A1 | MODIFIED VINYL ALCOHOL-BASED POLYMER AND METHOD FOR PRODUCING SAME, DISPERSION STABILIZER FOR SUSPENSION POLYMERIZATION, AND METHOD FOR PRODUCING VINYL-BASED RESIN | デンカ株式会社 | 2023-08-31 | — | — | WO | disclosed |
| CN-115487753-A | Method and device for preparing acid anhydride by partial oxidation of hydrocarbon with variable-concentration feed | 济南隆凯能源科技有限公司 | 2022-12-20 | — | — | CN | disclosed |
| EP-3030605-B1 | FLEXIBLE POLYMERIC MATERIAL WITH SHAPE RETENTION PROPERTIES | KIMBERLY CLARK CO (US) | 2019-08-07 | — | — | EP | disclosed |
| US-20160108194-A1 | Energy Absorbing Member | KIMBERLY-CLARK WORLDWIDE, INC. | 2016-04-21 | — | — | US | disclosed |
| CN-101085844-B | Thermoplastic elastomer composition and method for producing same | JSR CORP | 2011-07-20 | — | — | CN | disclosed |
| CN-100500755-C | Thermoplastic elastomer composition and method for producing same | JSR CORP (JP) | 2009-06-17 | — | — | CN | disclosed |
| CN-100434464-C | Thermoplastic elastomer composition and method for producing same | JSR CORP (JP) | 2008-11-19 | — | — | CN | disclosed |
| CN-1693353-A | Thermoplastic elastomer composition and method for producing same | JSR CORP (JP) | 2005-11-09 | — | — | CN | disclosed |
| CN-1693354-A | Thermoplastic elastomer composition and method for producing same | JSR CORP (JP) | 2005-11-09 | — | — | CN | disclosed |
| CN-1555395-A | Thermoplastic elastomer composition and method for producing same | JSR��ʽ���� | 2004-12-15 | — | — | CN | disclosed |
| EP-0935629-A1 | VARNISHED COMPOSITIONS, METHODS OF MAKING AND COMPONENTS MADE THEREFROM | Ranbar Electrical Materials, Inc. (US) | 1999-08-18 | — | — | EP | disclosed |
| WO-1999010405-A1 | VARNISHED COMPOSITIONS, METHODS OF MAKING AND COMPONENTS MADE THEREFROM | RANBAR ELECTRICAL MATERIALS, INC. (US) | 1999-03-04 | — | — | WO | disclosed |
| US-5585437-A | INCLUDES ADDUCT OF ALKYLENE OXIDE WITH SAPONIFIED COPOLYMER OF ETHYLENE AND VINYL ESTER OF SATURATED CARBOXYLIC ACID | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-12-17 | — | — | US | disclosed |
| US-4247436-A | SILANE, HYDROLYSED MALEIC ANHYDRIDE-VINYLTRIALKOXYSILANE COPOLYMER | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) | 1981-01-27 | — | — | US | disclosed |
| US-4195141-A | COPOLYMER OF TRIALKYOXYVINYLSILANE WITH MALEIC ANHYDRIDE, MODIFIED BY ALCOHOL | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) | 1980-03-25 | — | — | US | disclosed |