Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.55 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 11/20 | 0.54 |
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
| ▸ | FPGS | Q05932 | 2/20 | 0.50 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716717 | 1.00 | ERAP2 (0.55) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL9716722 | 1.00 | ERAP2 (0.55) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL7034241 | 0.95 | LNPEP (0.60) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL7034236 | 0.95 | LNPEP (0.60) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL9716809 | 0.88 | CA2 (0.54) | ERAP2LNPEPCA2CA1DHFR | |
| SCHEMBL9716814 | 0.88 | CA2 (0.54) | ERAP2LNPEPCA2CA1DHFR | |
| SCHEMBL9716816 | 0.88 | CA2 (0.54) | ERAP2LNPEPCA2CA1DHFR | |
| SCHEMBL1980652 | 0.88 | ITGB3 (0.57) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL1980150 | 0.88 | ITGB3 (0.57) | ERAP2LNPEPCA2CA1HPGDS | |
| SCHEMBL8847374 | 0.88 | ITGB3 (0.57) | ERAP2LNPEPCA2CA1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |