Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9716765 | 1.00 | BCL2 (0.45) | BCL2SIGMAR1KIF11CHRM2CHRM4 | |
| Fumaric Acid SCHEMBL9716794 | 0.97 | THRB (0.42) | BCL2SIGMAR1KIF11ALDH1A1LMNA | |
| Maleic Acid SCHEMBL9716788 | 0.97 | THRB (0.42) | BCL2SIGMAR1KIF11ALDH1A1LMNA | |
| Fumaric Acid SCHEMBL9716792 | 0.91 | SIGMAR1 (0.52) | BCL2SIGMAR1CHRM2CHRM4CHRM5 | |
| Maleic Acid SCHEMBL9716787 | 0.91 | SIGMAR1 (0.52) | BCL2SIGMAR1CHRM2CHRM4CHRM5 | |
| Maleic Acid SCHEMBL9716839 | 0.88 | BCL2 (0.47) | BCL2SIGMAR1KIF11CHRM2CHRM4 | |
| Fumaric Acid SCHEMBL9716852 | 0.88 | BCL2 (0.47) | BCL2SIGMAR1KIF11CHRM2CHRM4 | |
| Maleic Acid SCHEMBL9716806 | 0.87 | BCL2 (0.46) | BCL2SIGMAR1CHRM2CHRM4CHRM5 | |
| Fumaric Acid SCHEMBL9716886 | 0.87 | BCL2 (0.62) | BCL2SIGMAR1KIF11CHRM2CHRM4 | |
| Fumaric Acid SCHEMBL9716813 | 0.87 | BCL2 (0.46) | BCL2SIGMAR1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089529-A | Antiarrhythmia agents | NIPPON SHINYAKU CO., LTD. (JP) | 1992-02-18 | — | — | US | claimed |
| US-5089529-A | Antiarrhythmia agents | NIPPON SHINYAKU CO., LTD. (JP) | 1992-02-18 | — | — | US | disclosed |