Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066290 | 0.93 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1186104 | 0.92 | MEN1 (0.61) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL27519099 | 0.87 | NPC1 (0.67) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7563606 | 0.86 | F2 (0.45) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7328271 | 0.84 | ACR (0.58) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| 4-Guanidino-Benzoic Acid SCHEMBL7563601 | 0.83 | CA2 (0.50) | MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7330789 | 0.83 | ACR (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4214461 | 0.80 | PLG (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2ACR | |
| SCHEMBL7319794 | 0.80 | KMT2A (0.50) | MEN1KMT2AMAPTSMN1; SMN2ACR | |
| SCHEMBL20764440 | 0.79 | MEN1 (0.67) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110602-A | Solution or suspension in middle chain glyceride to inhibit degradation by digestive enzymes | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-05-05 | — | — | US | disclosed |
| EP-0287036-B1 | NEW PHARMACEUTICAL COMPOSITIONS COMPRISING ESTERS OR AMIDES AS ACTIVE INGREDIENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-04-10 | — | — | EP | disclosed |
| US-5004612-A | Dissolved in a middle chain glyceride of a fatty acid | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-04-02 | — | — | US | disclosed |
| US-4889723-A | SUSPENDED OR DISSOLVED IN GLYCERIDE; STABILITY | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-26 | — | — | US | disclosed |
| EP-0287036-A2 | New pharmaceutical compositions comprising esters or amides as active ingredients | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-10-19 | — | — | EP | disclosed |