Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.39 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL491216 | 0.95 | TSHR (0.48) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Styrene SCHEMBL10533310 | 0.94 | TSHR (0.45) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL11208181 | 0.89 | TSHR (0.56) | ALDH1A1LMNASMN1; SMN2KDM4EL3MBTL1 | |
| Styrene SCHEMBL8094495 | 0.89 | HCAR2 (0.49) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL18297752 | 0.89 | HCAR2 (0.49) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL11607106 | 0.89 | KDM4E (0.44) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL8175798 | 0.89 | ALDH1A1 (0.39) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL19582218 | 0.88 | ALDH1A1 (0.43) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL7213574 | 0.88 | TSHR (0.50) | HCAR2ALDH1A1LMNASMN1; SMN2KDM4E | |
| Styrene SCHEMBL6343507 | 0.88 | TSHR (0.42) | ALDH1A1LMNASMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5156707-A | Water resistant polyolefin coated paper, backing layer | FUJI PHOTO FILM CO., LTD. (JP) | 1992-10-20 | — | — | US | disclosed |