Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terbutaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.36 |
| ▸ | KYNU | Q16719 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5574192 | 0.83 | KMT2A (0.52) | KMT2ALMNACASP7HIF1ACYP3A4 | |
| SCHEMBL282065 | 0.83 | KMT2A (0.52) | KMT2ALMNACASP7HIF1ACYP3A4 | |
| SCHEMBL230513 | 0.83 | KMT2A (0.52) | KMT2ALMNACASP7HIF1ACYP3A4 | |
| SCHEMBL6350388 | 0.82 | KMT2A (0.51) | KMT2ALMNACASP7HIF1ACYP3A4 | |
| SCHEMBL16390915 | 0.77 | KMT2A (0.47) | KMT2ALMNACYP3A4TSHRCYP2C9 | |
| SCHEMBL10495232 | 0.76 | BLM (0.41) | KMT2ALMNACYP3A4TSHRBLM | |
| SCHEMBL10537170 | 0.76 | BLM (0.41) | KMT2ALMNACYP3A4TSHRBLM | |
| Hydrochloric Acid SCHEMBL10529768 | 0.75 | BLM (0.41) | KMT2ALMNACYP3A4TSHRBLM | |
| SCHEMBL10527044 | 0.73 | KMT2A (0.49) | KMT2ALMNACYP3A4TSHRCYP2C9 | |
| Terbutaline SCHEMBL27361880 | 0.71 | ADRB2 (0.79) | KMT2ALMNAADRB2CASP7HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357725-B1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF LUNG OBSTRUCTIONS | SMITH, Ulf Per Gustav (SE) | 1992-04-15 | — | — | EP | disclosed |