Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720188 | 0.66 | — | — | |
| SCHEMBL9719293 | 0.63 | TSHR (0.52) | — | |
| Tromethamine SCHEMBL28216031 | 0.63 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9644059 | 0.61 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3726684 | 0.59 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL342628 | 0.59 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.58 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193878 | 0.58 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3696191 | 0.58 | — | — | |
| Tromethamine SCHEMBL975 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515458-A1 | TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI. | HAFSLUND NYCOMED INNOVATION (SE) | 1992-12-02 | — | — | EP | disclosed |
| WO-1991012024-A1 | TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI | HAFSLUND NYCOMED INNOVATION AB (SE) | 1991-08-22 | — | — | WO | disclosed |