Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3696191 | 1.00 | — | — | |
| Tromethamine SCHEMBL17484 | 1.00 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL6427079 | 0.95 | — | — | |
| Tromethamine SCHEMBL2313359 | 0.95 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL4388579 | 0.95 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.95 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.95 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.95 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL6063594 | 0.95 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 842338 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9976170-B2 | Method for evaluating bacterial cell wall integrity | UNIVERSIDAD AUTONOMA DE MADRID (ES) | 2018-05-22 | — | — | US | claimed |
| US-9975941-B2 | Method for purifying teriparatide | RICHTER-HELM BIO TEC GMBH & CO. KG (DE) | 2018-05-22 | — | — | US | claimed |
| WO-2018089540-A1 | STABILIZED FORMULATIONS OF LIPID NANOPARTICLES | MODERNATX, INC. (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087779-A1 | TRANSDERMAL DELIVERY SYSTEM AND SPRAY-DEVICE | CIPLA LIMITED (IN) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089232-A1 | ENHANCING SEQUENCING PERFORMANCE IN SEQUENCING-BY-SYNTHESIS | QIAGEN SCIENCES LLC (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089231-A1 | PHOTOPROTECTIVE MIXTURES AS IMAGING REAGENTS IN SEQUENCING-BY-SYNTHESIS | QIAGEN SCIENCES LLC (US) | 2018-05-17 | — | — | WO | claimed |
| US-20180135128-A1 | METHODS FOR DETECTING CYSTIC FIBROSIS MUTATIONS USING MITRA TIP EXTRACTION | QUEST DIAGNOSTICS INVESTMENTS LLC (US) | 2018-05-17 | — | — | US | claimed |
| EP-3319598-A1 | IMPROVED TOPICAL KETOPROFEN FORMULATIONS | Elliptical Therapeutics, LLC (US) | 2018-05-16 | — | — | EP | claimed |
| EP-2693212-B1 | INSTRUMENT AND METHODS FOR ANALYSIS OF MANNOSE 6-PHOSPHATE | JAPAN CHEM RES (JP) | 2018-05-16 | — | — | EP | claimed |
| EP-3320050-A1 | SILICONE BASED EMULSION, METHOD FOR MAKING SAME, AND WATERBORNE CO-BINDER RESIN COMPOSITIONS COMPRISING SUCH EMULSIONS | Momentive Performance Materials Inc. (US) | 2018-05-16 | — | — | EP | claimed |
| US-3979206-A | Process for the preparation of magnesium | BILLITON RESEARCH B.V. (NL) | 1976-09-07 | — | — | US | claimed |
| US-3974310-A | Flame retardants for synthetic materials (I) | WHITE CHEMICAL CORPORATION (US) | 1976-08-10 | — | — | US | claimed |
| US-3974004-A | Extension of pot life of HTPB composite propellants by phosphine oxides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1976-08-10 | — | — | US | claimed |
| US-3963660-A | ANTI-ALLERGY | THE UPJOHN COMPANY (US) | 1976-06-15 | — | — | US | claimed |
| US-3962308-A | Process for converting esters to amine salts | THE UPJOHN COMPANY (US) | 1976-06-08 | — | — | US | claimed |
| US-3960669-A | Urine diagnostic test for fibrinolytic activity | ASSOCIATION FOR PHARMACOLOGIC RESEARCH, INC. (US) | 1976-06-01 | — | — | US | claimed |
| US-3953294-A | STORAGE STABLE REAGENT CONTAINING NONIONIC SURFACTANT | MALLINCKRODT, INC. (US) | 1976-04-27 | — | — | US | claimed |
| US-3951589-A | N,N,N-TRIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDICAMINE AND AMINOHYDROXY COMPOUND | CLAIROL INCORPORATED (US) | 1976-04-20 | — | — | US | claimed |
| US-3950133-A | POLYOXYALKYLENE, CATALYST | MALLINCKRODT, INC. (US) | 1976-04-13 | — | — | US | claimed |
| US-3947525-A | ETHYLENE-CHLOROTRIFLUOROETHYLENE COPOLYMER | ALLIED CHEMICAL CORPORATION (US) | 1976-03-30 | — | — | US | claimed |