Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL17484 | 1.00 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL975 | 1.00 | — | — | |
| Tromethamine SCHEMBL6427079 | 0.95 | — | — | |
| Tromethamine SCHEMBL2313359 | 0.95 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL4388579 | 0.95 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.95 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.95 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.95 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL6063594 | 0.95 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111406059-B | Europium complexes | 东曹株式会社 | 2023-04-18 | — | — | CN | disclosed |
| WO-2023277110-A1 | LIGHT EMITTING MATERIAL AND USE OF SAME | 国立大学法人千葉大学 | 2023-01-05 | — | — | WO | disclosed |
| US-20140206829-A1 | ISOSELECTIVE POLYMERIZATION OF EPOXIDES | CORNELL UNIVERSITY (US) | 2014-07-24 | — | — | US | disclosed |
| EP-0885192-B8 | DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS | US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) | 2012-05-16 | — | — | EP | disclosed |
| US-6686203-B2 | Histologic visualization of cyanoacrylate embolization | CALVO WILLIAM J (US) | 2004-02-03 | — | — | US | disclosed |
| US-20020031443-A1 | Histologic visualization of cyanoacrylate embolization | CALVO WILLIAM J (US) | 2002-03-14 | — | — | US | disclosed |
| EP-0885192-A1 | DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997027177-A2 | DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-07-31 | — | — | WO | disclosed |
| EP-0604483-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006235-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
| EP-0237080-B1 | PROCESS FOR THE PREPARATION OF L(-)-CARNITINE CHLORIDE STARTING FROM 3,4-EPOXYBUTYRIC ESTERS | ISTITUTO GUIDO DONEGANI S.p.A. (IT) | 1992-06-03 | — | — | EP | disclosed |
| US-4888433-A | CHIRAL HALOGENATED KETALS WHICH UNDERGO STEREOSELECTIVE REARRANGEMENT | ZAMBON, S.P.A. (IT) | 1989-12-19 | — | — | US | disclosed |
| EP-0299484-A1 | Process for the preparation of intermediates for the synthesis of fosfomycin | ZAMBON GROUP S.p.A. (IT) | 1989-01-18 | — | — | EP | disclosed |
| EP-0158913-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ALPHA-ARYLALKANOIC ACIDS AND INTERMEDIATES THEREOF | ZAMBON S.p.A. (IT) | 1988-07-20 | — | — | EP | disclosed |
| EP-0237080-A2 | Process for the preparation of L(-)-carnitine chloride starting from 3,4-epoxybutyric esters | ISTITUTO GUIDO DONEGANI S.p.A. (IT) | 1987-09-16 | — | — | EP | disclosed |