Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13284211 | 0.91 | HMGCR (0.68) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL11342543 | 0.89 | HMGCR (0.61) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9720676 | 0.87 | HMGCR (0.58) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9720549 | 0.84 | HMGCR (0.51) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5643886 | 0.84 | HMGCR (0.51) | HMGCRL3MBTL1ALDH1A1KDM4ENPC1 | |
| SCHEMBL10519355 | 0.84 | HMGCR (0.51) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL14797598 | 0.84 | HPGDS (0.49) | HMGCRALDH1A1TAAR1TAS1R3TAS1R1 | |
| SCHEMBL6962227 | 0.82 | ACHE (0.50) | HMGCRKMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL16920751 | 0.82 | IDO1 (0.40) | HMGCRMEN1KMT2AALDH1A1TAAR1 | |
| SCHEMBL7953584 | 0.80 | HSP90AB1 (0.45) | HMGCRMEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |