Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1262474 | 0.85 | HSP90AB1 (0.46) | HSP90AB1ALDH1A1POLBMAPTHSD17B10 | |
| SCHEMBL1262499 | 0.80 | L3MBTL1 (0.45) | HSP90AB1ALDH1A1TSHRHMGCRLMNA | |
| SCHEMBL7450427 | 0.79 | HSP90AB1 (0.47) | HSP90AB1ALDH1A1POLBMAPTHSD17B10 | |
| SCHEMBL2373430 | 0.78 | CES2 (0.59) | HSP90AB1ALDH1A1TSHRPOLBCES2 | |
| SCHEMBL14472134 | 0.77 | CYP1A2 (0.44) | ALDH1A1TSHRCES2CES1HSD17B10 | |
| SCHEMBL19235964 | 0.76 | HSP90AB1 (0.48) | HSP90AB1ALDH1A1TSHRPOLBCES2 | |
| SCHEMBL17420773 | 0.76 | HSP90AB1 (0.44) | HSP90AB1ALDH1A1TSHRPOLBMAPT | |
| SCHEMBL9720563 | 0.76 | HSP90AB1 (0.44) | HSP90AB1ALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL18535886 | 0.76 | HSP90AB1 (0.41) | HSP90AB1ALDH1A1TSHRPOLBKCNH2 | |
| SCHEMBL8804521 | 0.75 | DGAT1 (0.47) | ALDH1A1TSHRCES2CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |