Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720917 | 1.00 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPK1APPBACE1 | |
| SCHEMBL9720921 | 1.00 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPK1APPBACE1 | |
| SCHEMBL23660680 | 0.82 | LMNA (0.46) | LMNAMAPK1OPRL1GSK3AGSK3B | |
| SCHEMBL8912497 | 0.68 | TSHR (0.35) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL13103999 | 0.68 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL8912493 | 0.68 | TSHR (0.35) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL9846845 | 0.68 | ALDH1A1 (0.39) | ALDH1A1LMNAOPRL1KDM4EHSD17B10 | |
| SCHEMBL8914442 | 0.68 | TSHR (0.35) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL9846838 | 0.68 | ALDH1A1 (0.39) | ALDH1A1LMNAOPRL1KDM4EHSD17B10 | |
| SCHEMBL9846852 | 0.68 | ALDH1A1 (0.39) | ALDH1A1LMNAOPRL1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992000740-A2 | BIS-DIOXOPIPERAZINES AND THEIR USE AS PROTECTION AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-01-23 | — | — | WO | claimed |
| WO-2021144746-A1 | USE OF ICRF-193 DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF FOR THE PREVENTION OF CHRONIC CUMULATIVE CARDIOTOXICITY CAUSED BY THERAPY WITH ANTHRACYCLINE ANTICANCER DRUGS | UNIVERZITA KARLOVA V PRAZE (CZ) | 2021-07-22 | — | — | WO | disclosed |
| WO-1992000740-A2 | BIS-DIOXOPIPERAZINES AND THEIR USE AS PROTECTION AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-01-23 | — | — | WO | disclosed |