Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721269 | 0.90 | SENP1 (0.36) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9721361 | 0.84 | SENP1 (0.39) | HSD17B1HSD17B2SENP1BCL2BCL2L1 | |
| SCHEMBL9721314 | 0.77 | ERN1 (0.39) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL17753418 | 0.77 | HSD17B1 (0.47) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL6699314 | 0.76 | HSD17B1 (0.53) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL7105404 | 0.74 | HSD17B1 (0.48) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL6701966 | 0.72 | HSD17B1 (0.50) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL272034 | 0.71 | HSD17B1 (0.68) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL29429121 | 0.71 | HSD17B1 (0.68) | HSD17B1HSD17B2ESR2TP53TDP1 | |
| SCHEMBL29696046 | 0.71 | HSD17B1 (0.68) | HSD17B1HSD17B2ESR2TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |