Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.42 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721339 | 0.84 | TLR8 (0.51) | TLR8HSD17B1HSD17B2HSD17B14ESR1 | |
| SCHEMBL9721390 | 0.76 | TLR8 (0.43) | TLR8HSD17B1HSD17B2ESR1ESR2 | |
| SCHEMBL30719600 | 0.75 | TLR8 (0.57) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| SCHEMBL9721283 | 0.75 | MCL1 (0.47) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| SCHEMBL23496970 | 0.75 | TLR8 (0.57) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| SCHEMBL15326993 | 0.74 | TLR8 (0.49) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| SCHEMBL9721286 | 0.72 | APP (0.60) | MAPT | |
| SCHEMBL13678995 | 0.71 | TLR8 (0.70) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| SCHEMBL2030094 | 0.71 | TLR8 (0.49) | TLR8HSD17B1HSD17B2MCL1ESR1 | |
| Propane SCHEMBL17699241 | 0.70 | HSD17B1 (0.61) | HSD17B1HSD17B2ESR1ESR2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |