Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735709 | 0.88 | SIGMAR1 (0.47) | SIGMAR1MEN1KMT2AACHECYP3A4 | |
| SCHEMBL9721549 | 0.82 | ACHE (0.41) | MEN1KMT2AACHEBCHEBACE1 | |
| SCHEMBL12557616 | 0.80 | OPRM1 (0.47) | SIGMAR1 | |
| SCHEMBL728785 | 0.80 | CYP2D6 (0.49) | SIGMAR1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL18593039 | 0.77 | CACNA1G (0.35) | SIGMAR1CYP2C19ALDH1A1 | |
| SCHEMBL959849 | 0.77 | SMN1; SMN2 (0.49) | SIGMAR1MEN1KMT2ACYP2C19ADRA2A | |
| SCHEMBL27657086 | 0.76 | CYP2D6 (0.43) | SIGMAR1MEN1KMT2AACHECYP3A4 | |
| SCHEMBL9721852 | 0.76 | L3MBTL1 (0.47) | MEN1KMT2ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL14702320 | 0.75 | SIGMAR1 (0.48) | SIGMAR1MEN1KMT2AACHECYP3A4 | |
| SCHEMBL23534258 | 0.73 | SIGMAR1 (0.45) | SIGMAR1MEN1KMT2ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137896-A | Useful in treatment of gastrointestinal and psychic disorder; analgesic, antiemetic and antiulcer agent | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-11 | — | — | US | disclosed |
| US-5057525-A | Stimulators of gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-15 | — | — | US | disclosed |
| US-4962115-A | Stimulate motility of gastrointestinal system | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-09 | — | — | US | disclosed |
| EP-0076530-B1 | NOVEL N-(3-HYDROXY-4-PIPERIDINYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-11 | — | — | EP | disclosed |
| EP-0076530-A2 | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-04-13 | — | — | EP | disclosed |