Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722345 | 0.78 | POLB (0.33) | POLBGABRA1GABRB2 | |
| SCHEMBL9028225 | 0.77 | DHFR (0.38) | POLBDHFR | |
| SCHEMBL10460143 | 0.66 | GABRA1 (0.43) | POLBGABRA1GABRB2 | |
| SCHEMBL8702480 | 0.66 | SRD5A1 (0.39) | POLBGABRA1GABRB2 | |
| SCHEMBL11541695 | 0.66 | MEN1 (0.38) | POLB | |
| SCHEMBL7586358 | 0.65 | OSBP (0.31) | — | |
| SCHEMBL26065397 | 0.64 | HTR1A (0.32) | — | |
| SCHEMBL9028140 | 0.64 | KDM4E (0.38) | POLBDHFRGABRA1GABRB2 | |
| SCHEMBL9027401 | 0.63 | CYP26A1 (0.35) | DHFRGABRA1GABRB2 | |
| SCHEMBL9028351 | 0.63 | CYP19A1 (0.41) | DHFRGABRA1GABRB2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |