Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | MEN1 | O00255 | 9/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382900 | 0.85 | MEN1 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11545477 | 0.85 | MEN1 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10946051 | 0.84 | MEN1 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13811021 | 0.84 | MEN1 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13811001 | 0.80 | SRC (0.37) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL11065509 | 0.79 | MAOA (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10943626 | 0.77 | LMNA (0.39) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL10944706 | 0.77 | MAPT (0.59) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10949964 | 0.77 | SMN1; SMN2 (0.39) | MAPTMEN1KMT2AGAACTSB | |
| SCHEMBL10942288 | 0.77 | SMN1; SMN2 (0.39) | MAPTMEN1KMT2AGAACTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809368-B2 | Compounds affecting gap junction activity | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809368-B2 | Compounds affecting gap junction activity | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-08-19 | — | — | US | disclosed |
| US-20090143425-A1 | COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | US | disclosed |
| WO-2007127930-A2 | COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-11-08 | — | — | WO | disclosed |
| US-5104885-A | 5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine compounds and their use for treatment of malaria | CALSPAN CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| US-4980360-A | NONTOXIC AT HIGHER DOSAGES | CALSPAN CORPORATION (US) | 1990-12-25 | — | — | US | disclosed |
| US-4554279-A | PLASMODICIDAL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1985-11-19 | — | — | US | disclosed |
| US-4431807-A | PARASITICIDES; MALARIA; TISSUE AND BLOOD DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143425-A1 | COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY | GJB2, GJA1, GAP43 | MAPT 2537/4885MEN1 2903/4885KMT2A 4622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.