Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724264 | 0.83 | CYP4F2 (0.41) | LMNAPKMKDM4EALDH1A1 | |
| SCHEMBL9724121 | 0.78 | LMNA (0.62) | LMNAPKMDHODHKDM4EALDH1A1 | |
| SCHEMBL2671797 | 0.76 | ELANE (0.41) | ALDH1A1MAPT | |
| SCHEMBL14358894 | 0.76 | CYP1A2 (0.44) | DHODHKDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL9724146 | 0.76 | LMNA (0.64) | LMNAPKMKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL9494320 | 0.76 | LMNA (0.64) | LMNAPKMKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL9724227 | 0.75 | LMNA (0.62) | LMNAPKMDHODHKDM4EALDH1A1 | |
| SCHEMBL9729781 | 0.74 | ALDH1A1 (0.55) | LMNAPKMDHODHKDM4EALDH1A1 | |
| SCHEMBL3396098 | 0.73 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTGLAHPGD | |
| SCHEMBL3350745 | 0.72 | LMNA (0.62) | LMNAPKMDHODHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |