Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5443200 | 0.79 | ALDH1A1 (0.47) | HPGDKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11516631 | 0.78 | KDM4E (0.51) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL822678 | 0.78 | PTGER1 (0.56) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL7267265 | 0.78 | ALDH1A1 (0.55) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL4075651 | 0.77 | KDM4E (0.50) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11871844 | 0.77 | KDM4E (0.45) | HPGDKDM4EALDH1A1MEN1MAPK1 | |
| SCHEMBL10759331 | 0.76 | BCHE (0.51) | HPGDKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL23105448 | 0.74 | CNR1 (0.48) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL23105432 | 0.74 | FAAH (0.50) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL4080155 | 0.73 | CNR1 (0.65) | HPGDKDM4EALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098707-A | Thioimidazolium salts as anticoagulants for platelet aggregation inhibitors | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| US-5030644-A | Thrombolytic, fibrinolytic therapy | MERCK & CO., INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0411705-A1 | Imidazole compounds and their use as transglutaminase inhibitors | MERCK & CO. INC. (US) | 1991-02-06 | — | — | EP | disclosed |
| US-3993661-A | Quinone methide photograhpic reagent precursors | POLAROID CORPORATION (US) | 1976-11-23 | — | — | US | disclosed |