Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664194 | 0.81 | GRM5 (0.50) | GRM5CYP19A1ALDH1A1CYP2A6CYP11B2 | |
| SCHEMBL14302519 | 0.79 | PTGS2 (0.45) | GRM5CYP19A1ALDH1A1KDM4E | |
| SCHEMBL9288141 | 0.79 | TUBB4A (0.47) | GRM5ALDH1A1NOTUMNR3C1NR3C2 | |
| SCHEMBL25317305 | 0.76 | TUBB4A (0.50) | GRM5ALDH1A1NR3C1NR3C2GAA | |
| SCHEMBL19365958 | 0.76 | PTGS2 (0.53) | GRM5CYP19A1ALDH1A1NR3C1NR3C2 | |
| SCHEMBL10901975 | 0.76 | NR3C1 (0.39) | GRM5ALDH1A1NR3C1NR3C2GAA | |
| SCHEMBL12247671 | 0.75 | GRM5 (0.49) | GRM5ALDH1A1NR3C1NR3C2KDM4E | |
| SCHEMBL4630084 | 0.74 | GRM5 (1.00) | GRM5CYP19A1 | |
| SCHEMBL3531599 | 0.71 | CRHR1 (0.40) | GRM5CYP19A1KDM4E | |
| SCHEMBL4400768 | 0.71 | ALDH1A1 (0.56) | GRM5CYP19A1ALDH1A1CYP2A6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149814-A | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5120747-A | Antiallergens, antiinflammatory agent | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5070205-A | Chemical intermediate for anticoagulants | PFIZER INC. (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5063237-A | Antiallergens and antiinflammatory agents | PFIZER INC. (US) | 1991-11-05 | — | — | US | disclosed |
| US-4935430-A | Platelet activating factor antagonists | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | disclosed |