Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797182 | 0.88 | AKR1C3 (0.56) | L3MBTL1TP53AKR1C3MAPK1USP2 | |
| SCHEMBL9727563 | 0.88 | AKR1C3 (0.56) | L3MBTL1TP53AKR1C3MAPK1USP2 | |
| SCHEMBL9350706 | 0.85 | AKR1C3 (0.52) | L3MBTL1TP53AKR1C3ALDH1A1MAPK1 | |
| SCHEMBL9351906 | 0.85 | AKR1C3 (0.52) | L3MBTL1TP53AKR1C3ALDH1A1MAPK1 | |
| SCHEMBL9354611 | 0.85 | AKR1C3 (0.52) | L3MBTL1TP53AKR1C3ALDH1A1MAPK1 | |
| SCHEMBL9727348 | 0.84 | LMNA (0.55) | L3MBTL1TP53KDM4EAKR1C3ALDH1A1 | |
| SCHEMBL7379601 | 0.76 | MMP2 (0.64) | L3MBTL1TP53AKR1C3KMT2AMEN1 | |
| SCHEMBL19392491 | 0.76 | POLB (0.80) | PKMTSHRKDM4EPOLBALDH1A1 | |
| SCHEMBL7383735 | 0.76 | MMP2 (0.64) | PKML3MBTL1TP53POLBALDH1A1 | |
| SCHEMBL10702282 | 0.76 | MMP2 (0.64) | PKMTP53POLBAKR1C3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | disclosed |