Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9351906 | 1.00 | AKR1C3 (0.52) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9354611 | 1.00 | AKR1C3 (0.52) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9727563 | 0.97 | AKR1C3 (0.56) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9797182 | 0.97 | AKR1C3 (0.56) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9727320 | 0.85 | PKM (0.51) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9797671 | 0.84 | TP53 (0.51) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9797149 | 0.84 | TP53 (0.51) | AKR1C3TP53L3MBTL1LMNAMAPT | |
| SCHEMBL9727348 | 0.84 | LMNA (0.55) | AKR1C3TP53L3MBTL1LMNAALDH1A1 | |
| SCHEMBL10879808 | 0.83 | MMP2 (0.60) | AKR1C3L3MBTL1LMNAMAPTMAPK1 | |
| SCHEMBL7094393 | 0.83 | MMP2 (0.60) | AKR1C3TP53L3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384843-B1 | 1-Arylsulfonyl-2-piperidinone derivatives, process and intermediates for their preparation, their pharmaceutical use and compositions containing them | ROUSSEL UCLAF (FR) | 1994-08-31 | — | — | EP | claimed |
| EP-0384843-A2 | 1-Arylsulfonyl-2-piperidinone derivatives, process and intermediates for their preparation, their pharmaceutical use and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-08-29 | — | — | EP | claimed |
| EP-0384843-B1 | 1-Arylsulfonyl-2-piperidinone derivatives, process and intermediates for their preparation, their pharmaceutical use and compositions containing them | ROUSSEL UCLAF (FR) | 1994-08-31 | — | — | EP | disclosed |
| US-5041436-A | 1-arylsulphonyl-2-piperidinone derivatives, process and intermediates for the preparation thereof, their application as antispasmodics and compositions containing them | ROUSSEL UCLAF (FR) | 1991-08-20 | — | — | US | disclosed |
| US-5037822-A | Antispasmodic agent | ROUSSEL-UCLAF (FR) | 1991-08-06 | — | — | US | disclosed |
| EP-0384844-A2 | 1-Arylsulfonyl-pyrrolidine-2-thione or 1-arylsulfonyl-piperidine-2-thione derivatives, process for their preparation, their pharmaceutical use and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-08-29 | — | — | EP | disclosed |