Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727725 | 0.70 | AKR1B1 (0.32) | MAPT | |
| SCHEMBL6796574 | 0.63 | SLC6A4 (0.53) | — | |
| SCHEMBL9722386 | 0.61 | HMGCR (0.41) | ALOX5LMNAMAPTXBP1HIF1A | |
| SCHEMBL1760537 | 0.57 | HMGCR (0.64) | ALOX5LMNAMAPTXBP1HIF1A | |
| SCHEMBL8013800 | 0.57 | RXRA (0.51) | — | |
| SCHEMBL8641530 | 0.57 | CA2 (0.50) | LMNAHIF1A | |
| SCHEMBL1276072 | 0.56 | CYP3A4 (0.49) | LMNAMAPT | |
| SCHEMBL2678878 | 0.56 | ALOX5 (0.49) | ALOX5LMNAMAPTXBP1HIF1A | |
| SCHEMBL13940077 | 0.56 | SLC6A4 (0.45) | — | |
| SCHEMBL27498599 | 0.56 | ALOX5 (0.42) | ALOX5LMNAMAPTXBP1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |