SCHEMBL9727783

SCHEMBL9727783

C=CCOc1ccc2c(c1)C(C)C(Cc1ccc(OC)cc1)O2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
MAPT P10636 3/20 0.42
GAA P10253 2/20 0.42
USP2 O75604 1/20 0.39
POLB P06746 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 1/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
SLC5A2 P31639 2/20 0.37
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
KMT2A Q03164 1/20 0.36
TLR9 Q9NR96 1/20 0.36
CA12 O43570 4/20 0.34
CA1 P00915 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9727495 0.80 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2CYP3A4MEN1KMT2A
SCHEMBL9727708 0.77 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
SCHEMBL9727705 0.74 ABCB1 (0.41) ALDH1A1SMN1; SMN2TP53CYP3A4ALOX15
1-Allyloxy-4-Methoxybenzene SCHEMBL2843640 0.69 ALDH1A1 (0.57) ALDH1A1MAPTGAAUSP2POLB
SCHEMBL14441303 0.68 ALDH1A1 (0.58) ALDH1A1MAPTGAAUSP2POLB
SCHEMBL10405477 0.68 MEN1 (0.36) ALDH1A1MAPTGAASMN1; SMN2TSHR
SCHEMBL10401481 0.68 MAPT (0.37) ALDH1A1MAPTGAAPOLBSMN1; SMN2
SCHEMBL10401577 0.67 MAPT (0.36) ALDH1A1MAPTGAAPOLBSMN1; SMN2
SCHEMBL5355917 0.67 CA12 (0.55) ALDH1A1MAPTGAASMN1; SMN2TP53
SCHEMBL10401465 0.66 CA12 (0.36) ALDH1A1MAPTGAAUSP2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5091533-A Treating allergies, cardiovascular disorders, inflammation MERCK FROSST CANADA, INC. (CA) 1992-02-25 US disclosed
EP-0447189-A1 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors MERCK FROSST CANADA INC. (CA) 1991-09-18 EP disclosed