Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731303 | 0.90 | PARP1 (0.39) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL9731401 | 0.82 | ERN1 (0.39) | MAPTMEN1KMT2AALDH1A1CASP1 | |
| SCHEMBL9732624 | 0.81 | PTPN1 (0.46) | MAPTMEN1KMT2AGAAATM | |
| SCHEMBL9730974 | 0.74 | IGFBP3 (0.34) | MEN1KMT2ALMNAPOLB | |
| SCHEMBL9731139 | 0.74 | NSD2 (0.48) | MAPTMEN1KMT2AALDH1A1CASP1 | |
| SCHEMBL8764571 | 0.73 | CCR1 (0.53) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL2748318 | 0.73 | LMNA (0.50) | MEN1KMT2ATLR8ALDH1A1CASP1 | |
| SCHEMBL29996665 | 0.73 | LMNA (0.50) | MEN1KMT2ATLR8ALDH1A1CASP1 | |
| SCHEMBL19643450 | 0.72 | CA12 (0.51) | MAPTMEN1KMT2AGAATLR8 | |
| SCHEMBL9730944 | 0.71 | MAPT (0.55) | MAPTMEN1KMT2AGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5122537-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-06-16 | — | — | US | disclosed |