Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729755 | 0.83 | SORD (0.49) | LMNA | |
| SCHEMBL4813569 | 0.83 | SMO (0.50) | LMNASMOLRRK2NPSR1 | |
| SCHEMBL9729927 | 0.81 | MEN1 (0.60) | LMNANPSR1 | |
| SCHEMBL25142290 | 0.80 | HRH4 (0.49) | LMNASMOLRRK2 | |
| SCHEMBL12497703 | 0.78 | HRH4 (0.57) | NPSR1 | |
| SCHEMBL11981553 | 0.77 | SMN1; SMN2 (0.50) | LMNANPSR1 | |
| SCHEMBL15114915 | 0.77 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL15286832 | 0.76 | LMNA (0.53) | LMNASMOLRRK2NPSR1CTSS | |
| SCHEMBL28217397 | 0.75 | SMN1; SMN2 (0.53) | LMNANPSR1 | |
| SCHEMBL16091229 | 0.75 | CYP1A2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5138058-A | Diabetic screening | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0384370-A1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |