Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 7/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734695 | 0.91 | KMT2A (0.40) | MAPTNR1H2NR1H3PDK2F10 | |
| SCHEMBL10433122 | 0.90 | F10 (0.40) | PDK2F10HRH4 | |
| SCHEMBL10433092 | 0.87 | F10 (0.36) | F10RIPK2 | |
| SCHEMBL9733195 | 0.86 | HRH4 (0.34) | F10HRH4 | |
| SCHEMBL9734404 | 0.85 | MAOA (0.43) | NPC1RAB9AMAPTPDK2F10 | |
| SCHEMBL9733799 | 0.85 | MAPT (0.40) | RAB9AMAPT | |
| SCHEMBL9733434 | 0.82 | SLC6A2 (0.39) | F10HRH4 | |
| SCHEMBL9733018 | 0.82 | HRH4 (0.34) | PGRHRH4L3MBTL1 | |
| SCHEMBL9733913 | 0.82 | TDP1 (0.37) | RAB9AMAPTF10HRH4TDP2 | |
| SCHEMBL9734559 | 0.81 | RXFP1 (0.39) | MAPTHRH4TDP2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |