Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733018 | 0.85 | HRH4 (0.34) | L3MBTL1HRH4PARP1PARP10AVPR1A | |
| SCHEMBL9733434 | 0.85 | SLC6A2 (0.39) | HRH4MEN1KMT2AF10SLC6A2 | |
| SCHEMBL9733727 | 0.85 | PDE4B (0.36) | TDP1L3MBTL1PDE4B | |
| SCHEMBL9734559 | 0.84 | RXFP1 (0.39) | L3MBTL1HRH4MEN1KMT2AMAPT | |
| SCHEMBL9733614 | 0.83 | ALDH1A1 (0.35) | HRH4 | |
| SCHEMBL10433117 | 0.83 | ESR1 (0.34) | TDP1L3MBTL1PDE4BMEN1KMT2A | |
| SCHEMBL9733797 | 0.82 | MEN1 (0.40) | TDP1MEN1KMT2APTPRCPARP1 | |
| SCHEMBL9733284 | 0.82 | HTR1A (0.37) | KMT2ABACE1 | |
| SCHEMBL9734695 | 0.82 | KMT2A (0.40) | TDP1L3MBTL1MEN1KMT2APTPRC | |
| SCHEMBL9733318 | 0.82 | S100A4 (0.38) | L3MBTL1HRH4MAPTRAB9ATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |