Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 12/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733913 | 0.85 | TDP1 (0.37) | SLC6A2SLC6A4SLC6A3HRH4F10 | |
| SCHEMBL9733018 | 0.85 | HRH4 (0.34) | SLC6A2SLC6A4SLC6A3HRH4 | |
| SCHEMBL9734559 | 0.84 | RXFP1 (0.39) | HRH4MEN1KMT2A | |
| SCHEMBL9733614 | 0.83 | ALDH1A1 (0.35) | HRH4 | |
| SCHEMBL9733284 | 0.82 | HTR1A (0.37) | KMT2ABACE1 | |
| SCHEMBL9733318 | 0.82 | S100A4 (0.38) | HRH4F10 | |
| SCHEMBL9733797 | 0.82 | MEN1 (0.40) | MEN1KMT2A | |
| SCHEMBL9733534 | 0.82 | TP53 (0.35) | HRH4F10 | |
| SCHEMBL9734695 | 0.82 | KMT2A (0.40) | F10MEN1KMT2A | |
| SCHEMBL9734404 | 0.82 | MAOA (0.43) | SLC6A2SLC6A4F10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |