SCHEMBL9733018

SCHEMBL9733018

CC1(C)C=C(n2ccccc2=O)c2cc(F)ccc2C1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.34
ACHE P22303 1/20 0.34
HTR1A P08908 2/20 0.33
ALDH1A1 P00352 1/20 0.32
PPARG P37231 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NCOR2 Q9Y618 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
PARP1 P09874 3/20 0.32
PARP10 Q53GL7 1/20 0.31
AVPR1A P37288 1/20 0.31
ELOVL6 Q9H5J4 1/20 0.31
PGR P06401 1/20 0.31
SRD5A1 P18405 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9733913 0.85 TDP1 (0.37) HRH4L3MBTL1PARP1PARP10AVPR1A
SCHEMBL9733434 0.85 SLC6A2 (0.39) HRH4SLC6A2SLC6A4SLC6A3
SCHEMBL9733534 0.84 TP53 (0.35) HRH4ALDH1A1PARP1PARP10
SCHEMBL9734559 0.84 RXFP1 (0.39) HRH4ALDH1A1PPARGNPSR1RXFP1
SCHEMBL9733614 0.83 ALDH1A1 (0.35) HRH4ALDH1A1RXFP1
SCHEMBL9734695 0.82 KMT2A (0.40) ALDH1A1L3MBTL1SRD5A1
SCHEMBL9733797 0.82 MEN1 (0.40) ACHEHTR1AALDH1A1CYP3A4PARP1
SCHEMBL9733284 0.82 HTR1A (0.37) HTR1AALDH1A1PGR
SCHEMBL9733318 0.82 S100A4 (0.38) HRH4L3MBTL1PGR
SCHEMBL10433122 0.81 F10 (0.40) HRH4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5132307-A TETRALIN COMPOUNDS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1992-07-21 US disclosed
EP-0368160-A1 Tetralin derivatives MERCK PATENT GmbH (DE) 1990-05-16 EP disclosed