Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733318 | 0.85 | S100A4 (0.38) | NPC1RAB9AMAPTF10PDK2 | |
| SCHEMBL9733434 | 0.82 | SLC6A2 (0.39) | SLC6A2SLC6A4MEN1KMT2AF10 | |
| SCHEMBL9734695 | 0.81 | KMT2A (0.40) | ALDH1A1MEN1KMT2AMAPTF10 | |
| SCHEMBL10433122 | 0.80 | F10 (0.40) | ALDH1A1SMN1; SMN2F10PDK2KDM4E | |
| SCHEMBL10433092 | 0.80 | F10 (0.36) | F10 | |
| SCHEMBL9733913 | 0.79 | TDP1 (0.37) | SLC6A2SLC6A4MEN1KMT2ARAB9A | |
| SCHEMBL9733018 | 0.79 | HRH4 (0.34) | SLC6A2SLC6A4ALDH1A1L3MBTL1 | |
| SCHEMBL9734559 | 0.78 | RXFP1 (0.39) | HTR2CHTR2BALDH1A1MEN1KMT2A | |
| SCHEMBL8085176 | 0.78 | MAOA (0.42) | MAOACYP1A2ADRA2ASLC6A2HTR2C | |
| SCHEMBL9733614 | 0.77 | ALDH1A1 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |