Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733797 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1PTPRCBCHE | |
| SCHEMBL9733966 | 0.78 | ALDH1A1 (0.33) | KMT2AALDH1A1PGRSMN1; SMN2 | |
| SCHEMBL9733645 | 0.76 | GAA (0.37) | MEN1KMT2AALDH1A1PTPRCS100A4 | |
| SCHEMBL8122945 | 0.72 | CHRM1 (0.35) | CHRM1MEN1KMT2AALDH1A1PTPRC | |
| SCHEMBL10433223 | 0.71 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1PTPRCS100A4 | |
| SCHEMBL9733018 | 0.69 | HRH4 (0.34) | ALDH1A1ACHEHTR1APARP1PGR | |
| SCHEMBL9733614 | 0.68 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL9733322 | 0.68 | KCNJ1 (0.36) | MEN1KMT2AALDH1A1BCHEACHE | |
| SCHEMBL9375452 | 0.67 | CHRM1 (0.36) | CHRM1MEN1KMT2AALDH1A1PTPRC | |
| SCHEMBL9733284 | 0.67 | HTR1A (0.37) | KMT2AALDH1A1HTR1APGRCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |