Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 3/20 | 0.38 |
| ▸ | S100A4 | P26447 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733353 | 0.87 | CHRM1 (0.37) | MEN1KMT2APTPRCS100A4BCHE | |
| SCHEMBL9733645 | 0.84 | GAA (0.37) | MEN1KMT2APTPRCS100A4ALDH1A1 | |
| SCHEMBL9733434 | 0.82 | SLC6A2 (0.39) | MEN1KMT2A | |
| SCHEMBL9733018 | 0.82 | HRH4 (0.34) | ACHEALDH1A1PARP1CYP3A4HTR1A | |
| SCHEMBL9733913 | 0.82 | TDP1 (0.37) | MEN1KMT2APTPRCCES1TDP2 | |
| SCHEMBL9734559 | 0.81 | RXFP1 (0.39) | MEN1KMT2AALDH1A1TDP2LMNA | |
| SCHEMBL9733614 | 0.80 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL9733318 | 0.79 | S100A4 (0.38) | S100A4TDP2NR1H2NR1H3MAPT | |
| SCHEMBL9734695 | 0.79 | KMT2A (0.40) | MEN1KMT2APTPRCALDH1A1TDP2 | |
| SCHEMBL9733284 | 0.79 | HTR1A (0.37) | KMT2AALDH1A1CASP3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |