Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733497 | 0.89 | EGLN2 (0.38) | EGLN2DRD2DRD3PGRHSP90AA1 | |
| SCHEMBL9735233 | 0.86 | PGR (0.36) | EGLN2DRD2DRD3PGRHSP90AA1 | |
| SCHEMBL9733641 | 0.85 | OTUD7B (0.31) | OTUD7BDYRK1A | |
| SCHEMBL9733508 | 0.84 | PGR (0.32) | PGR | |
| SCHEMBL9735213 | 0.82 | POLB (0.33) | PGR | |
| SCHEMBL9733777 | 0.81 | EGLN2 (0.33) | EGLN2OTUD7BDYRK1AAR | |
| SCHEMBL8085352 | 0.81 | PDE4A (0.39) | EGLN2DRD2DRD3KDM1ACYP1A2 | |
| SCHEMBL9733168 | 0.80 | ABCC9 (0.34) | — | |
| SCHEMBL9733001 | 0.79 | OTUD7B (0.35) | DRD2DRD3PGROTUD7BCYP1A2 | |
| SCHEMBL9734137 | 0.77 | BACE1 (0.35) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |