Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834477 | 0.85 | PPARG (0.46) | TSHRCYP3A4ERN1ALDH1A1HSD17B10 | |
| SCHEMBL8022860 | 0.81 | MGAM (0.46) | TSHRCYP3A4ALDH1A1HSD17B10MAPT | |
| SCHEMBL7314986 | 0.81 | ADRB2 (0.60) | TSHRCYP3A4ERN1ALDH1A1HSD17B10 | |
| SCHEMBL5154594 | 0.81 | ALDH1A1 (0.61) | TSHRERN1SCN1ASCN2ASCN3A | |
| SCHEMBL10460587 | 0.81 | TSHR (0.51) | TSHRERN1SCN1ASCN2ASCN3A | |
| SCHEMBL1638832 | 0.80 | TSHR (0.57) | TSHRCYP3A4ERN1SCN1ASCN2A | |
| SCHEMBL7310001 | 0.80 | NPC1 (0.56) | CYP3A4SCN1ASCN2ASCN3AALDH1A1 | |
| SCHEMBL9535875 | 0.79 | TSHR (0.61) | TSHRCYP3A4ERN1SCN1ASCN2A | |
| SCHEMBL3230316 | 0.79 | TSHR (0.65) | TSHRCYP3A4ERN1SCN1ASCN2A | |
| SCHEMBL29500171 | 0.79 | TSHR (0.65) | TSHRCYP3A4ERN1SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132424-A | Anticholesterol, treatment of atherosclerosis | THE UPJOHN COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0425541-A1 | PYRAZOLO-AZOLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990001031-A1 | PYRAZOLO-PYRROLO-PYRIMIDINE-DIONES | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |