Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 8/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535718 | 0.85 | HTR2A (0.34) | HTR2AHTR2CDRD2ADRA2AADRA2C | |
| SCHEMBL26759016 | 0.82 | MEN1 (0.34) | HTR2AHTR2CDRD2ADRA2AADRA2C | |
| SCHEMBL9200651 | 0.81 | ABCB1 (0.44) | — | |
| SCHEMBL4873739 | 0.80 | HTT (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL4846177 | 0.80 | HTT (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL6987633 | 0.80 | HTT (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL4873736 | 0.80 | HTT (0.39) | MEN1ALDH1A1KMT2A | |
| SCHEMBL9735438 | 0.79 | HTR1A (0.40) | HTR2CDRD2DRD3MEN1ALDH1A1 | |
| SCHEMBL9736762 | 0.79 | ALOX5 (0.41) | IDO1MEN1ALDH1A1KMT2A | |
| SCHEMBL4848406 | 0.78 | HTR2A (0.32) | HTR2AHTR2CDRD2ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |